Effect of igf-i administration on growth hormone secretion in obese subjects

ABSTRACT OBJECTIVE: The reduction of spontaneous and stimulated growth hormone (GH) secretion in obesity could reflect an increase of the inhibitory effect of insulin growth factor I (IGF-I)

on somatotroph secretion. DESIGN: In the present study we aimed to verify the effect of low dose recombinant human IGF-I (20 µg/kg subcutaneously (s.c.) at 0 min) on 3 h-spontaneous GH

secretion (mGHc, 0–180 min) and on the GH response to growth hormone releasing hormone (GHRH) (1 µg/kg i.v. at+180 min) in obesity. SUBJECTS: Five obese women with abdominal adiposity (OB,

age, mean±s.e.m.: 31±7.13 y; BMI: 32.04±3.69 kg/m2) and eight age-matched lean women (NW, 28.3±1.2 y; 20.1±0.5 kg/m2) were studied. RESULTS: The mGHc and GHRH-induced GH response in OB

(1.0±0.7 µg/l; AUC180–270 min: 688.6±202.4 µg/l min, respectively) were lower than in NW (2.6±0.8 µg/l, 1315.9±189.9 µg/l min, respectively, _P_<0.05). The administration of rhIGF-I

increased circulating IGF-I levels in OB and NW to the same extent (339.0±50.39 and 420.3±30.5 µg/l, respectively). The rhIGF-I administration did not affect mGHc in OB or NW (1.1±0.9 and

3.2±1.0 µg/l, respectively) but inhibited (_P_<0.05) the GH response to GHRH in OB (324.2±153.1 µg/l) and NW (730.2±288.1 µg/l). CONCLUSIONS: Our study shows that the administration of

low dose rhIGF-I reduces the somatotroph responsiveness to GHRH in obesity as well as in normal subjects. Access through your institution Buy or subscribe This is a preview of subscription

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November 2024 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, F Tassone, L Gianotti, F

Lanfranco, C Ganzaroli, SE Oleandri, M Taliano, E Ghigo & M Maccario * Italy F Tassone, L Gianotti, F Lanfranco, C Ganzaroli, SE Oleandri, M Taliano, E Ghigo & M Maccario *

Department of Pharmacology, University of Milan, Italy EE Muller Authors * F Tassone View author publications You can also search for this author inPubMed Google Scholar * L Gianotti View

author publications You can also search for this author inPubMed Google Scholar * F Lanfranco View author publications You can also search for this author inPubMed Google Scholar * C

Ganzaroli View author publications You can also search for this author inPubMed Google Scholar * SE Oleandri View author publications You can also search for this author inPubMed Google

Scholar * M Taliano View author publications You can also search for this author inPubMed Google Scholar * EE Muller View author publications You can also search for this author inPubMed 

Google Scholar * E Ghigo View author publications You can also search for this author inPubMed Google Scholar * M Maccario View author publications You can also search for this author

inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to E Ghigo. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Tassone, F., Gianotti, L.,

Lanfranco, F. _et al._ Effect of IGF-I administration on growth hormone secretion in obese subjects. _Int J Obes_ 25 (Suppl 1), S41–S42 (2001). https://doi.org/10.1038/sj.ijo.0801696

Download citation * Issue Date: 01 May 2001 * DOI: https://doi.org/10.1038/sj.ijo.0801696 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * IGF-I *

GH * GHRH * obesity * insulin