Targeting microbial metabolites to treat autism

Targeting microbial metabolites to treat autism


Play all audios:

Loading...

A first-in-class therapeutic that targets neuroactive microbial metabolites in the gut shows promising target engagement, safety and behavioral improvements in adolescents with autism


spectrum disorder. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution RELEVANT ARTICLES Open Access articles citing this


article. * LARGE-SCALE METAGENOMIC ANALYSIS OF ORAL MICROBIOMES REVEALS MARKERS FOR AUTISM SPECTRUM DISORDERS * Paolo Manghi * , Michele Filosi *  … Enrico Domenici _Nature Communications_


Open Access 11 November 2024 ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99


/ 30 days cancel any time Learn more Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on


SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about


institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Cryan, J. F. et al. _Physiol. Rev._ 99, 1877–2013 (2019). Article  CAS  Google Scholar  * Campbell, A. S.


et al. _Nat. Med._ https://doi.org/10.1038/s41591-022-01683-9 (2022). Article  PubMed  Google Scholar  * Needham, B. D. et al. _Nature_ https://doi.org/10.1038/s41586-022-04396-8 (2022).


Article  PubMed  Google Scholar  * Swann, J. R., Spitzer, S. O. & Diaz Heijtz, R. _Metabolites_ 10, 172 (2020). Article  CAS  Google Scholar  * Hsiao, E. Y. et al. _Cell_ 155, 1451–1463


(2013). Article  CAS  Google Scholar  * Needham, B. D. et al. _Biol. Psychiatry_ 89, 451–462 (2021). Article  CAS  Google Scholar  * Zheng, Y. et al. _Front. Neurosci_ 15, 738220 (2021).


Article  Google Scholar  * Hoban, A. E. et al. _Transl. Psychiatry_ 6, e774 (2016). Article  CAS  Google Scholar  * Phan, B. N. et al. _Nat. Neurosci._ 23, 375–385 (2020). Article  CAS 


Google Scholar  * Muller, R. A. & Fishman, I. _Trends Cogn. Sci._ 22, 1103–1116 (2018). Article  Google Scholar  * Kujawa, A. et al. _Biol. Psychiatry Cogn. Neurosci. Neuroimaging_ 1,


345–352 (2016). PubMed  PubMed Central  Google Scholar  * Tan, Q. et al. _Autism Res._ 14, 1820–1836 (2021). Article  Google Scholar  * Yap, C. X. et al. _Cell_ 184, 5916–5931 e5917 (2021).


Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS R.D.H. is supported by the Swedish Research Council, the Swedish Brain Foundation, the Frimurare Barnhus Foundation and the


European Union (ITN SmartAge, grant agreement number 859890). P.G. is supported by Inserm, the Université de Paris, the Horizon 2020 Framework Program of the European Union (grant agreement


no. 874721/PREMSTEM), the ANR, the Fondation Grace de Monaco, the Fondation des Gueules Cassées and an additional grant from “Investissement d’Avenir-ANR-11-INBS-0011”–NeurATRIS. J.R.S. is


supported by the National Institute for Health Research Southampton Biomedical Research Centre, Biotechnology and Biological Sciences Research Council (BB/W00139X/1) and Medical Research


Council (MR/W003597/1). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Neuroscience, Karolinska Institutet, Biomedicum, Stockholm, Sweden Rochellys Diaz Heijtz, Pierre Gressens 


& Jonathan R. Swann * University of Rouen Normandy, INSERM U1239, Rouen, France Rochellys Diaz Heijtz * Université de Paris, NeuroDiderot, Inserm, Paris, France Pierre Gressens * School


of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK Jonathan R. Swann Authors * Rochellys Diaz Heijtz View author publications You can also


search for this author inPubMed Google Scholar * Pierre Gressens View author publications You can also search for this author inPubMed Google Scholar * Jonathan R. Swann View author


publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Rochellys Diaz Heijtz. ETHICS DECLARATIONS COMPETING INTERESTS The authors


declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Diaz Heijtz, R., Gressens, P. & Swann, J.R. Targeting microbial


metabolites to treat autism. _Nat Med_ 28, 448–450 (2022). https://doi.org/10.1038/s41591-022-01711-8 Download citation * Published: 14 February 2022 * Issue Date: March 2022 * DOI:


https://doi.org/10.1038/s41591-022-01711-8 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not


currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative