Targeting microbial metabolites to treat autism

A first-in-class therapeutic that targets neuroactive microbial metabolites in the gut shows promising target engagement, safety and behavioral improvements in adolescents with autism

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article. * LARGE-SCALE METAGENOMIC ANALYSIS OF ORAL MICROBIOMES REVEALS MARKERS FOR AUTISM SPECTRUM DISORDERS * Paolo Manghi * , Michele Filosi *  … Enrico Domenici _Nature Communications_

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Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS R.D.H. is supported by the Swedish Research Council, the Swedish Brain Foundation, the Frimurare Barnhus Foundation and the

European Union (ITN SmartAge, grant agreement number 859890). P.G. is supported by Inserm, the Université de Paris, the Horizon 2020 Framework Program of the European Union (grant agreement

no. 874721/PREMSTEM), the ANR, the Fondation Grace de Monaco, the Fondation des Gueules Cassées and an additional grant from “Investissement d’Avenir-ANR-11-INBS-0011”–NeurATRIS. J.R.S. is

supported by the National Institute for Health Research Southampton Biomedical Research Centre, Biotechnology and Biological Sciences Research Council (BB/W00139X/1) and Medical Research

Council (MR/W003597/1). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Neuroscience, Karolinska Institutet, Biomedicum, Stockholm, Sweden Rochellys Diaz Heijtz, Pierre Gressens 

& Jonathan R. Swann * University of Rouen Normandy, INSERM U1239, Rouen, France Rochellys Diaz Heijtz * Université de Paris, NeuroDiderot, Inserm, Paris, France Pierre Gressens * School

of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK Jonathan R. Swann Authors * Rochellys Diaz Heijtz View author publications You can also

search for this author inPubMed Google Scholar * Pierre Gressens View author publications You can also search for this author inPubMed Google Scholar * Jonathan R. Swann View author

publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Rochellys Diaz Heijtz. ETHICS DECLARATIONS COMPETING INTERESTS The authors

declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Diaz Heijtz, R., Gressens, P. & Swann, J.R. Targeting microbial

metabolites to treat autism. _Nat Med_ 28, 448–450 (2022). https://doi.org/10.1038/s41591-022-01711-8 Download citation * Published: 14 February 2022 * Issue Date: March 2022 * DOI:

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