Important roles of mechanical force and hydraulic pressure in kidney function

Access through your institution Buy or subscribe Tubule epithelial cells (TECs) regulate the reabsorption of water and electrolytes; however, the role of mechanical force in driving fluid

transport by TECs is unclear. Using a microfluidic platform to mimic fluid transport, Choudhury and colleagues now show that TECs act as mechanobiological fluid pumps, actively generating

hydraulic pressure gradients across the epithelium. The trans-epithelial fluidic flux, which occurs in an apical-to-basal direction in normal TECs, declines with increasing hydraulic

pressure until a stall pressure is reached. Moreover, the researchers show that TECs change their gene expression profiles and spatial arrangements of ion exchangers in response to changes

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ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Choudhury, M. I. et al. Kidney

epithelial cells are active mechano-biological fluid pumps. _Nat. Commun._ 13, 2317 (2022) Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *

Nature Reviews Nephrology http://www.nature.com/nrneph Susan J. Allison Authors * Susan J. Allison View author publications You can also search for this author inPubMed Google Scholar

CORRESPONDING AUTHOR Correspondence to Susan J. Allison. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Allison, S.J. Important roles of mechanical

force and hydraulic pressure in kidney function. _Nat Rev Nephrol_ 18, 413 (2022). https://doi.org/10.1038/s41581-022-00593-w Download citation * Published: 06 June 2022 * Issue Date: July

2022 * DOI: https://doi.org/10.1038/s41581-022-00593-w SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

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