The risk of angiosarcoma following primary breast cancer

SUMMARY Lymphangiosarcoma of the upper extremity is a rare and aggressive tumour reported to occur following post-mastectomy lymphoedema (Stewart–Treves syndrome). Haemangiosarcoma, a

related rare tumour, has occasionally been reported to occur in the breast following irradiation. We conducted a case-control study using the University of Southern California-Cancer

Surveillance Program, the population-based cancer registry for Los Angeles County, to evaluate the relationship between invasive female breast cancer and subsequent upper extremity or chest

lymphangiosarcoma and haemangiosarcoma together referred to as angiosarcoma. Cases were females diagnosed between 1972 and 1995 with angiosarcoma of the upper extremity (_n_ = 20) or chest

(_n_ = 48) who were 25 years of age or older and residing in Los Angeles County when diagnosed. Other sarcomas at the same anatomic sites were also studied. Controls were females diagnosed

with cancers other than sarcoma during the same time period (_n_ = 266 444). Cases and controls were then compared with respect to history of a prior invasive epithelial breast cancer. A

history of breast cancer increased the risk of upper extremity angiosarcoma by more than 59-fold (odds ratio [OR] = 59.3, 95% confidence interval [95% CI] = 21.9–152.8). A strong increase in

risk after breast cancer was also observed for angiosarcoma of the chest and breast (OR = 11.6, 95% CI = 4.3–26.1) and for other sarcomas of the chest and breast (OR = 3.3, 95% CI =

1.1–1.7). SIMILAR CONTENT BEING VIEWED BY OTHERS ANGIOSARCOMA OF BONE: A RETROSPECTIVE STUDY OF THE EUROPEAN MUSCULOSKELETAL ONCOLOGY SOCIETY (EMSOS) Article Open access 02 July 2020

INCIDENCE AND SITE SPECIFIC CHARACTERISTICS OF ANGIOSARCOMA IN JAPAN USING A POPULATION-BASED NATIONAL CANCER REGISTRY FROM 2016 TO 2019 Article Open access 22 March 2025 SURVIVAL AND

PROGNOSTIC FACTORS AMONG DIFFERENT TYPES OF LIPOSARCOMAS BASED ON SEER DATABASE Article Open access 13 January 2025 ARTICLE PDF CHANGE HISTORY * _ 16 NOVEMBER 2011 This paper was modified 12

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_Cancer_ 30: 562–572. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Preventive Medicine, University of Southern California

School of Medicine, USC/NOR MS 44, 1441 Eastlake Avenue, Los Angeles, 90033, CA, USA W Cozen, L Bernstein, F Wang & T M Mack * Department of Pathology, University of Southern California

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INFORMATION Correspondence to: W Cozen RIGHTS AND PERMISSIONS From twelve months after its original publication, this work is licensed under the Creative Commons

Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Cozen, W., Bernstein, L., Wang, F. _et al._ The risk of angiosarcoma following primary breast cancer. _Br J Cancer_ 81, 532–536 (1999).

https://doi.org/10.1038/sj.bjc.6690726 Download citation * Received: 20 August 1998 * Revised: 04 January 1999 * Accepted: 28 January 1999 * Published: 10 September 1999 * Issue Date: 01

October 1999 * DOI: https://doi.org/10.1038/sj.bjc.6690726 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * breast cancer * Stewart–Treves

syndrome * lymphangiosarcoma * haemangiosarcoma * angiosarcoma * radiation * lymphoedema